S-ALKİL 4-(4-KLOROFENİL)-5-(PİROL-2-İL)-1,2,4-TRİAZOL-3-TİYOL TÜREVLERİNİN SENTEZİ VE ÖZELLİKLERİ
نویسندگان
چکیده
Objective: The aim of the work was to develop effective methods for synthesis promising heterocyclic systems based on pyrrole and 1,2,4-triazole. In process realizing this aim, 10 new S-alkyl 4-(4-chlorophenyl)-5-(pyrrole-2-yl)-1,2,4-triazole-3-thiol derivatives were synthesized. Material Method: Chemical structures synthesized compounds characterized with elemental analysis, 1H-NMR, LC-MS techniques. biological potential substances estimated by molecular docking method ADME analysis. Result Discussion: An optimum has been developed. modeling studies, found be similar known drugs in some respects. interaction each molecule crystal cyclooxygenase-2, lanosterol-14α-demethylase active site considered silico. Pharmacokinetic parameters a number have predicted
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ژورنال
عنوان ژورنال: Ankara Üniversitesi Eczac?l?k Fakültesi dergisi
سال: 2023
ISSN: ['1015-3918', '2564-6524']
DOI: https://doi.org/10.33483/jfpau.1280492